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02-24-16 | Posted by

The newest dimple destroyer has some interesting and unexpected roots.

Collagenase clostridium histolyticum (CCH) is being studied for its potential effects on releasing skin irregularities and thus, smoothing the skin. CCH is currently FDA-approved in the United States as XIAFLEX® for the treatment of adult Dupuytren’s contracture, which is a hand deformity that causes hard knots of tissue to form under the skin that result in fingers being pulled in a bent position, and also for men with Peyronie’s disease that can cause a curvature deformity in their male organ.

A Phase 2b study of CCH for treating cellulite will soon be underway, conducted by Endo International. The Phase 2b trial is expected to enroll 350 women 18 years or older in the United States. Each study patient will receive up to three treatment sessions of CCH or placebo, spaced 21 days apart. Twelve injections will be directed into cellulite dimples across the left or right buttock or left or right posterior thigh. Cellulite severity will be assessed by each patient and clinician using two photonumeric cellulite severity scales developed by Endo with the help of experts and reviewed by the FDA, known as the Photonumeric Cellulite Severity Scale (PCSS). PCSS are 5-point scales ranging from 0 (no cellulite – #SkinnyBitches) to 4 (severe cellulite – AHEM…) that measure improvement in the appearance of cellulite. In addition, an independent, blinded five-member panel of aesthetic clinicians will also evaluate before and after CCH treatments using the PCSS.

According to Bonnie Marting, ARNP, Director of Aesthetics at Anushka Cosmedical Centre in West Palm Beach, FL, “We welcome further studies on this powerful drug and its potential application for cellulite reduction. Women are so desperate to find effective longterm solutions to this all too common condition, and CCH holds some exciting promise for the future.”

CCH cellulite approval may be a long way off, since cellulite is not exactly high priority for the FDA. So if you can’t wait, these are 3 other options to consider:

Cellfina is an FDA cleared minimally invasive office procedure that addresses the primary structural reason we get cellulite – fibrous bands. It is a single treatment with results that have been clinically proven to last at least two years. The treatment takes about 45 minutes in a doctor’s office. Cost: $4,000 and up depending on how many areas are treated in one session.





Venus Freeze uses multi-polar radiofrequency energy with Pulsed Magnetic fields to produce a therapeutic heat matrix over the skin to stimulate the body’s natural healing process. These magnetic fields also increase O2, nutrients and blood flow to the skin. The results is firmer, tighter skin and less dents and dimples. The treatment takes about 30 minutes and there is no downtime. A series of 6-8 sessions plus periodic maintenance is recommended. Cost: $1,200 and up for a series

Cellulaze is slightly more invasive. The system uses a laser fiber that gets threaded through a tiny tube called a cannula and inserted through a slit incision. The laser fiber smooths out bumps, releases fibrous bands that tug on your skin can cause dimples, and stimulates collagen production to improve skin tone and texture. The treatment takes 60-90 minutes, typically a single treatment is done, and results last one year or longer. Cost: $6,000 and up depending on how many areas are treated

You know what they say – summer bodies are made in winter… So we all better get cracking.

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