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07-01-18 | Posted by

Dr. Pearl E. Grimes is a leading international figure on vitiligo and pigmentation disorders, treating patients from around the world. She is the director of the Vitiligo and Pigmentation Institute of Southern California and a dedicated clinician, researcher and speaker, lecturing on pigmentation disorders, cosmetic procedures, chemical peeling, fillers and microdermabrasion.

Dr. Grimes serves as a Clinical Professor of Dermatology at UCLA and is an active member of the American Academy of Dermatology, American Society of Dermatologic Surgery, American Dermatological Association, Society of Investigative Dermatology, Dermatology Foundation, International Pigment Cell Society and Women’s Dermatologic Society.

Among her many achievements, Dr. Grimes has been listed as LA Magazine’s Super Doctors and has been recognized on the Best Doctors of America list for the last 12 years.

BITB spoke with Dr. Grimes about working as a dermatologist and effective treatments for women during each decade of life.


1. When and how did you first become interested in working in the field of dermatology?
I became interested in the field of dermatology after medical school. I was attracted to the diversity of dermatology, which encompasses myriad sub-specialties. The specialty of dermatology allowed me to help children and adults, practice internal medicine, view pathology slides, perform skin surgery and also perform aesthetic procedures. I was intrigued! Dermatology appeals to both my scientific side and my artistic side.

The specialty of dermatology is truly my passion, and I have never doubted or regretted my decision. In fact, my love for this creative field has evolved over several decades as I’ve grown as a dermatologist and lifelong scientific explorer. Over the years, I have been dedicated to, and fascinated by, treating a wide spectrum of pigmentary disorders, from everyday aesthetic concerns such as melasma and post-inflammatory hyperpigmentation to the complexities of vitiligo. I am equally interested in helping my patients with ethnic hair loss and I am very excited about breakthroughs in the field. I love helping my patients, and I love what I do.

2. What are the most effective treatments for a woman who wants to maintain healthy, beautiful skin in her 20s, 30s-40s, 50 plus, etc.?


  • Broad spectrum sun protection
  • Topical antioxidants
  • Moisturization
  • Hydration is key in the 20’s. Studies suggest that the skin damage starts in the early 20’s, thus it may be helpful to start using retinol


  • Broad Spectrum sunscreens minimize free radical damage from UV light
  • Retinoids/Retinols are a must. Consider peptide and hyaluronic acid for moisturization

Late 30’s-40’s:

  • Begin to consider Botulinum toxin as it helps to minimize wrinkles and facial lines
  • Superficial and medium-depth peels are great for rejuvenation. Examples include salicylic or lactic acid peels, TCA for medium-depth peeling
  • Antioxidant serums protect skin from premature aging
  • Peptide serums help to stimulate collagen

50’s +:

  • Sun protection
  • Gentle cleanser helps to remove dirt without stripping the skin of moisture
  • Ceramide moisturizer gives skin plumpness
  • Fillers are key to restoring volume
  • Retinoids/Retinols are key in the 50’s
  • Peptide and growth factors along help severe rhytids in lighter FST, rhytidectomy if needed
  • Aggressive lasers/peels such as fractional and CO2 lasers

3. What products are in your makeup bag and on your bathroom vanity?

In the makeup bag:


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